Homocysteine thiolactone inhibits insulin signaling, and glutathione has a protective effect
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چکیده
منابع مشابه
Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation.
Hyperhomocysteinemia and insulin resistance are independent factors for cardiovascular disease. Most of the angiotoxic effects of homocysteine are related to the formation of homocysteine thiolactone and the consequent increase in oxidative stress. We have recently found that homocysteine thiolactone inhibits insulin receptor tyrosine kinase activity, which results in decreased phosphatidylinos...
متن کاملCalcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation.
Homocysteine thiolactone is formed in all cell types studied thus far as a result of editing reactions of some aminoacyl-tRNA synthetases. Because inadvertent reactions of thiolactone with proteins are potentially harmful, the ability to detoxify homocysteine thiolactone is essential for biological integrity. This work shows that a single specific enzyme, present in mammalian but not in avian s...
متن کاملProtective mechanisms against protein damage in hyperhomocysteinemia: Systemic and renal detoxification of homocysteine-thiolactone
Homocysteine (Hcy) and its metabolite Hcy-thiolactone (HTL) are implicated in cardiovascular disease (CVD). Recent studies show that HTL is a predictor of acute myocardial infarction in CVD patients, independent of established risk factors and plasma total Hcy. HTL is formed in all cell types as a result of error-editing reactions in protein biosynthesis. Its ability to N-homocysteinylate prote...
متن کاملProtective Effects of Acetylation on the Pathological Reactions of the Lens Crystallins with Homocysteine Thiolactone
Various post-translational lens crystallins modifications result in structural and functional insults, contributing to the development of lens opacity and cataract disorders. Lens crystallins are potential targets of homocysteinylation, particularly under hyperhomocysteinemia which has been indicated in various eye diseases. Since both homocysteinylation and acetylation primarily occur on prote...
متن کاملUrinary excretion of homocysteine-thiolactone in humans.
BACKGROUND A metabolite of homocysteine (Hcy), the thioester Hcy-thiolactone, has been implicated in coronary heart disease in humans. Because inadvertent reactions of Hcy-thiolactone with proteins can lead to cell and tissue damage, the ability to detoxify or eliminate Hcy-thiolactone is essential for biological integrity. We examined the hypothesis that the human body eliminates Hcy-thiolacto...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2001
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.0.0270085